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Robert Zimmermann

Open Positions
Open Position 10: Metabolism of Bis(monoacylglycero)phosphate
» »  Application info

Projects
Maria Anna Pribasnig: Functional characterization of alpha/beta hydrolase fold proteins

Closed projects
Margret Paar (Pöschl): The role of fatty acid binding proteins in lipolysis
Ulrike Taschler: Localisation and Functional Characterization of RE Hydrolyzing Enzymes in Stellate Cells
Christoph Heier: Molecular mechanisms regulating lipolysis
Doris Jäger: The impact of CGI-58 on lipid metabolism
Irina Mrak: On the role of Bcl-2 in lipolyis
Matthias Romauch: Functional analysis of lipolysis inducing mediators
Gernot Grabner: The role of Monoglyceride lipase (MGL) in energy metabolism and endocannabinoid signalling

Further Information
Curriculum Vitae (41 kB)
Publication List (external Link)
Collaborators (48 kB)
Grants (52 kB)

 







Robert Zimmermann
Institute of Molecular Biosciences
Karl Franzens Universität Graz
Heinrichstrasse 31/2
8010 Graz

e-Mail: robert.zimmermann@uni-graz.at
phone: 43 316 380 1914
fax: +43 316 380 9016
web: http://imb.uni-graz.at

Catabolism of Bis(monoacylglycero)phosphate

The main subject studied in R. Zimmermann’s group is the functional characterization of lipolytic enzymes. Ongoing work is focused on the physiological role and regulation of acylglycerol and retinylester hydrolases, and on the development of specific inhibitors for ATGL. Within the next funding period we will start to investigate the metabolism of the lysosomal lipid bis(monoacylglycero)phosphate [BMP, also known as lysobisphosphatidic acid (LBPA)]. This lipid is found in inner membrane structures of lysosomes. It is resistant to acid hydrolases and forms a “platform” for lysosomal lipid-degrading enzymes. Therefore, BMP is considered as key activator for lysosomal lipid sorting and membrane digestion. Furthermore, BMP is a lipid marker for phospholipidosis and was identified as antigen for anti-phospholipid antibodies in patients suffering from anti-phospholipid syndrome. To date, very little is known about the synthesis and catabolism of this lipid. In a promising new project we identified a mammalian enzyme which degrades BMP with high specific activity. Further studies will focus on the role of this enzyme in lipid metabolism in vitro and in vivo.

Laboratory know-how and infrastructure

The Graz university cluster and the Institute of Molecular Biosciences (IMB) at the University of Graz is an internationally renowned center for lipid and energy metabolism research. State-of-the-art animal studies were made possible by the opening of the institute’s new animal facility under SPF conditions including a physiological unit (TSE Phenomaster). Therefore, the majority of our experimental work can be done at the IMB or in collaborating laboratories within the Graz network (lipidomics.uni-graz.at, lipotox.uni-graz.at). Special expertise is available in our group for gene cloning, protein expression, lipid and protein analysis, enzyme characterization, cell culture techniques, and generation and characterization of mutant mice.


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