Molecular Mechanisms of Bacterial Pathogenicity
The threat of antibiotic-resistant microorganisms is rising, hence more efforts need to be invested into research that focuses on the molecular characterization and lifestyle of microbial pathogens. The outcome of these investigations will result in the discovery of specific targets for the development of novel anti-microbial treatment and vaccine strategies. We are interested in investigating molecular pathogenesis for some important human pathogens, with an emphasis on bacterial adaptation in response to environmental and host conditions. Our research is focused on specialized catabolic/metabolic/regulatory pathways and surface-exposed structures, which facilitate adaptation, colonization, persistence, and optimized growth. Two model organisms are currently investigated: Vibrio cholerae and Haemophilus influenzae.
Laboratory know-how and infrastructureThe proposed projects will be carried out at the Institute of Molecular Biosciences, University of Graz. All necessary equipment such as array analysis/laser scanner, cell culture facilities, bacterial biohazard class 2 facilities, animal facilities, flow benches, and confocal and epifluorescence microscopes will be provided by the institution. The applicant’s laboratory is capable of handling and genetically manipulating pathogenic bacteria as well as using infection models. Standard procedures include also protein expression and purification, and expression profiling.