Ceramide-associated Enzymes in Intracellular Signalling
Prof. Hermetter’s research deals with the role of enzymes and glycero(phospho)lipids as components of membranes and lipoproteins, as mediators in cellular (patho)biochemistry, and their application as analytical tools. Fluorescence spectroscopy is being used as a main technique to investigate the behaviour of these biomolecules in solution and supramolecular systems. One project deals with lipid oxidation and the effects of oxidized lipids on intracellular signalling. Another line of research is devoted to the development and application of fluorescence and chip technology for proteome screening and functional analysis of lipolytic enzymes in medicine and biotechnology.
Laboratory know-how and infrastructureFluorescence enzymatic assays, nanosecond fluorescence, organic lipid and fluorophore synthesis, cell culture, biochip production and application (spotter, reader), functional proteomics (2D-gelelectrophoresis, laser scanner), fluorescence microscopy, signal transduction, lipid and membrane technology.