Enzyme-Catalyzed Asymmetric Hydrations
Particular research interests are:
(1) Enzymatic functionalization of electronically activated alkenes via asymmetric addition of H2O using (CoA-dependent) hydratases. The latter transformation furnishes nonracemic hydroxy-compounds with 100% atom economy. The use of 'minimized' CoA-substrates, such as N-acetylcysteamine derivatives opens the way to preparative-scale applications.
(2) Selective activation of hydroxy-compounds derived from renewable resources using enzymatic phosphorylation at the expense of cheap and innocuous inorganic poly- or di-phosphate as phosphate donor. This methodology has the potential to replace inefficient and 'dirty' chemical methodology based on sulfonates and/or Mitsunobu-conditions.
(3) Enzymatic carboxylation of aromatics or heteroaromatics to furnish the corresponding aryl-carboxylic acids in a regioselective fashion. Thus, CO2 is being used as a raw material for the production of valuable organic compounds.
Laboratory know-how and infrastructure
Organic synthesis: Asymmetric synthesis of bioactive compounds using biocatalytic methods, experience in the synthesis of pheromones, vitamins, antibiotics, flavour- and fragrance compounds and pharmaceuticals.
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