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Kurt Faber

Projects
Matthias Pickl: Minimal substrates for enoyl-CoA hydratases

Closed projects
Markus Schober: Structure, Function and Mechanism of Inverting Alkylsulfatases
Barbara Ueberbacher: Enzyme-Catalyzed Cascade-Reactions
Katharina Weitzer (Durchschein): Unusual reactions catalyzed by flavoproteins from the Old Yellow Enzyme Family
Michael Tösch: Asymmetric biocatalytic Cannizzaro reactions

Further Information
Curriculum Vitae (42 kB)
Publication List (external Link)
Collaborators (46 kB)
Grants (54 kB)

 







Kurt Faber
Institute of Chemistry - Organic & Bioorganic Chemistry
Karl Franzens Universität Graz
Heinrichstrasse 28
8010 Graz

e-Mail: kurt.faber@uni-graz.at
phone: +43 316 380 5332
fax: +43 316 380 9840
web: http://biocatalysis.uni-graz.at

Enzyme-Catalyzed Asymmetric Hydrations

The driving force of Dr. Faber’s research is the search of biocatalytic methods for (asymmetric) organic synthesis, where traditional (chemical) methodology is lacking, inefficient, or non-selective.
Particular research interests are:
(1) Enzymatic functionalization of electronically activated alkenes via asymmetric addition of H2O using (CoA-dependent) hydratases. The latter transformation furnishes nonracemic hydroxy-compounds with 100% atom economy. The use of 'minimized' CoA-substrates, such as N-acetylcysteamine derivatives opens the way to preparative-scale applications.
(2) Selective activation of hydroxy-compounds derived from renewable resources using enzymatic phosphorylation at the expense of cheap and innocuous inorganic poly- or di-phosphate as phosphate donor. This methodology has the potential to replace inefficient and 'dirty' chemical methodology based on sulfonates and/or Mitsunobu-conditions.
(3) Enzymatic carboxylation of aromatics or heteroaromatics to furnish the corresponding aryl-carboxylic acids in a regioselective fashion. Thus, CO2 is being used as a raw material for the production of valuable organic compounds.

Laboratory know-how and infrastructure

Biocatalysis: Growth of bacteria, fungi, yeasts and extremophiles; enzyme purification, characterization and immobilization; shake flask experiments, fermentation (up to 10L), screening of non-natural substrates, biocatalytic transformations using (fermenting or resting) whole-cells or isolated enzymes, biotransformation upscaling up to 100g substrate, enzyme reactions in organic solvents, selectivity-enhancement, modelling of kinetics.

Organic synthesis: Asymmetric synthesis of bioactive compounds using biocatalytic methods, experience in the synthesis of pheromones, vitamins, antibiotics, flavour- and fragrance compounds and pharmaceuticals.



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