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Horst Lechner

Transformation of non natural substrates by norcoclaurine synthase

Thesis Committee
Wolfgang Kroutil (Supervisor)
Karl Gruber
Peter Macheroux

Further Information
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  Horst Lechner
Institute of Chemistry - Organic & Bioorganic Chemistry
Karl Franzens Universität Graz
Heinrichstrasse 28
8010 Graz

e-Mail: horst.lechner@edu.uni-graz.at
phone: +43 316 380 8644


  • Lechner, H. et al.: Biocatalysts for the formation of three- to six-membered carbo- and heterocycles. Biotechnol Adv 2015.

  • Wuensch, C., Lechner, H. et al.: Asymmetric Biocatalytic Cannizzaro-Type Reaction. ChemCatChem 2013, 5, 1744-1748

  • Kroutil, W. et al.: Asymmetric preparation of prim-, sec- and tert-amines employing selected biocatalysts. Organic Process Research & Development 2013, 17, 751?759

  • Simon, R.C. et al.: Concise Chemoenzymatic Three Step Total Synthesis of Isosolenopsin Through Medium Engineering. European Journal of Organic Chemistry 2013, 3397-3402.

  • Resch et al.:Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine-Containing Substrates Chemistry A European Journal 2012, 18 (41), 13173-13179

  • Fuchs, M. et al.: Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation-transamination cascade. RSC Advances 2012, 2 (15), 6262-6265

    Curriculum vitae

    Born in Austria
    Internal DK student, selected through DK hearing 2011, starting date: 01.10.2011


    2011 -  PhD program DK Molecular Enzymology, University of Graz, Austria
    2007 - 2011 Master of Science in Chemistry/ Biochemistry, University Graz, Austria
    2010 - 2011 Diploma thesis at the Institute of Chemistry/Bioorganic chemistry, University of Graz, Austria
    10/08 - 01/09 Exchange semester at University of Oklahoma/Norman, OK, USA
    2005 - 2007 Bachelor of Science in Chemistry/ Biochemistry, University Graz, Austria

    Research Stay

    10/ 2013 – 04/ 2014 Laboratory of David Baker, University of Washington, Seattle, USA

    Posters and Oral Presentations

    07/ 2015 BIOTRANS Conference 2015 (Vienna A); poster presentation
    06/ 2014 Trends in Enzymology Conference, Manchester, UK, poster presentation
    07/ 2013 Biotrans 2013, Manchester, GB, poster presentation
    07/ 2013 10th Congress on Catalysis Applied to Fine Chemicals (CAFC10), Turku, Finnland, oral presentation
    12/ 2012 “Enzymes and Signals“ joint research summit with the DK Molecular Mechanisms in Cell Signaling (Vienna), Graz, oral presentation
    10/ 2012 EMBO Conference: Catalytic Mechanisms by Biological Systems, Groningen, Netherlands

    Professional Experiences

    08/ 2009 - 09/ 2009 Student research assistant, Department of Structure Biology and Research Centre Applied Biocatalysis Graz, University of Graz
    03/ 2008 - 06/ 2008 Project lab, University of Graz Institute of Chemistry/Department of physical chemistry
    03/ 2007 - 06/ 2007 Project lab, University of Graz, Institute of Chemistry/Department of Organic & Bioorganic Chemistry

    Teaching activities

    2010 -  Teaching assistant in the lab course “Organic chemistry 1” (CHE144), University of Graz
    2006 -  Chemistry tutor in a preparation course for the qualifying test at Medical University of Graz at the BG/BRG Bruck – ClubAHS
    10/09 - 01/10 Teaching assistant at the lab course “basic chemistry” (CHE115) University of Graz
    10/06- 01/07 Teaching assistant in the lab course “Physics for Chemists” (CHE101) University of Graz

    Functions within the DK

    07/ 2013 Organization of the 10th Doc Day, NAWI Graz Doctoral Schools Molecular Biology and Biochemistry & Molecular Biosciences and Biotechnology, Graz, Austria
    2012/13 Organization of DK literature seminar WS12/13 and SS13

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