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Michael Tösch (finished 2014)

Asymmetric biocatalytic Cannizzaro reactions

Thesis Committee
Kurt Faber (Supervisor)

Further Information
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  Michael Tösch
Institute of Chemistry - Organic & Bioorganic Chemistry
Karl Franzens Universität Graz
Heinrichstrasse 28
8010 Graz

e-Mail: michael.toesch@edu.uni-graz.at
phone: +43-316-380-5349


  • Toesch, M., Schober, M., and Faber, K., Deracemisation of sec-Alcohols via Enantio-convergent Hydrolysis of rac-Sulfate Esters. [/DOI] Practical Methods in Biocatalysis & Biotransformations, J. Whittall, P. W. Sutton, W. Kroutil (eds.) 2016; 3 (Wiley-VCH), 45-50.

  • Toesch, M., Schober, M., and Faber, K., Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities. Appl Microbiol Biotechnol 2014; 98 (4), 1485-1496.

  • Toesch M. et al.:Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities. Appl. Microbiol. Biotechnol. 2014, 98, 1485-1496.

  • Schober, M., et al.: K. One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases. Angewandte Chemie International Edition, 2013; 11, 3277-3279.

  • Fuchs, M. et al.: : Chemoenzymatic Asymmetric Total Synthesis of (R)-Lasiodiplodin Methyl Ether through a Sulfatase-Based Deracemization Process . 2013; Eur. J. Org. Chem,: 356-361.
  • Schober, M. et al: The substrate spectrum of the inverting sec-alkylsulfatase Pisa1 . View Issue TOC, 2012; 354 (9): 1737-1742.

    Curriculum vitae

    Born in Austria
    Internal DK student, selected through DK hearing 2011, starting date: 01.10.2011


    2011 - 2014 PhD program DK Molecular Enzymology, University of Graz, Austria
    2008 - 2011 Master of Science in Biochemistry and Molecular Biology, University of Graz
    2004 - 2008 Bachelor of Science in Chemistry, University of Graz

    poster and oral presentations

    07/ 2014 Gordon Research Conference, Rhode Island, USA, poster presentation
    07/ 2013 Biotrans Conference 2013, poster presentation, Manchester, UK
    06/ 2013 ECCLS 2013, poster presentation, Barcelona, Spain
    02/ 2013 9th Doc Day NAWI Graz Doctoral Schools Molecular Biology and Biochemistry & Molecular Biosciences and Biotechnology, Graz, Austria, oral presentation
    12/ 2012 “Enzymes and Signals“ joint research summit with the DK Molecular Mechanisms in Cell Signaling (Vienna), Graz, poster presentation
    05/ 2012 Graduate Seminar 2012 DK Molecular Enzymology, Graz, Austria
    04/ 2012 MECP12 conference Graz; poster presentation
    09/ 2012 6th International Congress on Biocatalytics Hamburg, Germany; poster presentation

    Professional Experiences

    2009 Summer student in the research group of Dr. Kurt Faber
    2008 Employee at the FWF - project „LIPOTOX“

    Teaching activities

    WS 2012/13 teaching assistant in the lab course “molecular analytics and spectrometry“ (CHE153) University Graz
    WS 2011/12 teaching assistant in the lab course “molecular analytics and spectrometry“ (CHE153) University Graz
    2009 - 2011 Tutor in the lab course “Biochemical Practice” (MOL405), University of Graz
    2007 - 2009 Tutor in the lab course “Chemical Informatics”(CHE118), University of Graz
    2008 Tutor in the lab course “Biochemical Practice I” (CHE154), University of Graz

    Functions within the DK

    07/ 2011 Organization of the NAWI Graz DocDay in Chemistry, Graz, Austria

    Science communication

    10/ 2011 Assistant at „Lange Nacht der Chemie“ 2011 (“night of Chemistry”; introducing Chemistry to general public)

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